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1

New mechanisms of skin innate immunity: ASK1-mediated keratinocyte differentiation regulates the expression of β-defensins, LL37, and TLR2

Koji Sayama, Hitoshi Komatsuzawa, Kenshi Yamasaki, Yuji Shirakata, Yasushi Hanakawa, Kazuhisa Ouhara, Sho Tokumaru, Xiuju Dai, Mikiko Tohyama, Peter ten Dijke, Motoyuki Sugai, Hidenori Ichijo, Koji Ha

Journal:

European Journal of Immunology

Year:

2005

Language:

english

File:

PDF, 280 KB

english, 2005

2

IL-17 and IL-22 mediate IL-20 subfamily cytokine production in cultured keratinocytes via increased IL-22 receptor expression

Mikiko Tohyama, Yasushi Hanakawa, Yuji Shirakata, Xjuju Dai, Lujun Yang, Satoshi Hirakawa, Sho Tokumaru, Hidenori Okazaki, Koji Sayama, Koji Hashimoto

Journal:

European Journal of Immunology

Year:

2009

Language:

english

File:

PDF, 5.59 MB

english, 2009

3

Differential Effects of Desmoglein 1 and Desmoglein 3 on Desmosome Formation

Hanakawa, Yasushi, Amagai, Masayuki, Shirakata, Yuji, Yahata, Yoko, Tokumaru, Sho, Yamasaki, Kenshi, Tohyama, Mikiko, Sayama, Koji, Hashimoto, Koji

Journal:

The Journal of Investigative Dermatology

Year:

2002

Language:

english

File:

PDF, 1.36 MB

english, 2002

4

Advanced cholangiocarcinoma in a patient with stage I primary sclerosing cholangitis

Mikiko Ueda, Taro Nakamura, Taiji Tohyama, Fumiki Kushihata, Yasuo Honda, Nobuaki Kobayashi

Journal:

Journal of Hepato-Biliary-Pancreatic Sciences

Year:

2003

Language:

english

File:

PDF, 264 KB

english, 2003

5

Keratinocyte G2/M Growth Arrest by 1,25-Dihydroxyvitamin D3 Is Caused by Cdc2 Phosphorylation Through Wee1 and Myt1 Regulation

Dai, Xiuju, Yamasaki, Kenshi, Yang, Lujun, Sayama, Koji, Shirakata, Yuji, Tokumara, Sho, Yahata, Yoko, Tohyama, Mikiko, Hashimoto, Koji

Journal:

The Journal of Investigative Dermatology

Year:

2004

Language:

english

File:

PDF, 535 KB

english, 2004

6

Suppressor of cytokine signaling 3 negative regulation of signal transducer and activator of transcription 3 in platelet-derived growth factor-induced fibroblast migration

Hiroshi NAGAI, Sho TOKUMARU, Koji SAYAMA, Yuji SHIRAKATA, Yasushi HANAKAWA, Satoshi HIRAKAWA, Xiuju DAI, Mikiko TOHYAMA, Lujun YANG, Koji HASHIMOTO

Journal:

The Journal of Dermatology

Year:

2007

Language:

english

File:

PDF, 157 KB

english, 2007

7

Possible association of vascular endothelial growth factor with the development of edema in drug-induced hypersensitivity syndrome

Satoshi HIRAKAWA, Hidenori OKAZAKI, Koji SAYAMA, Mikiko TOHYAMA, Koji HASHIMOTO

Journal:

The Journal of Dermatology

Year:

2011

Language:

english

File:

PDF, 214 KB

english, 2011

8

New aspects of drug-induced hypersensitivity syndrome

Mikiko TOHYAMA, Koji HASHIMOTO

Journal:

The Journal of Dermatology

Year:

2011

Language:

english

File:

PDF, 433 KB

english, 2011

9

Carbamazepine-induced drug-induced hypersensitivity syndrome in a 14-year-old Japanese boy

Yuka Suzuki, Mitsumasa Fukuda, Mikiko Tohyama, Manami Ishikawa, Masaki Yasukawa, Eiichi Ishii

Journal:

Year:

2008

Language:

english

File:

PDF, 286 KB

english, 2008

10

SOCS1-Negative Feedback of STAT1 Activation Is a Key Pathway in the dsRNA-Induced Innate Immune Response of Human Keratinocytes

Dai, Xiuju, Sayama, Koji, Yamasaki, Kenshi, Tohyama, Mikiko, Shirakata, Yuji, Hanakawa, Yasushi, Tokumaru, Sho, Yahata, Yoko, Yang, Lujun, Yoshimura, Akihiko

Journal:

The Journal of Investigative Dermatology

Year:

2006

Language:

english

File:

PDF, 254 KB

english, 2006

11

STAT5a/PPARγ Pathway Regulates Involucrin Expression in Keratinocyte Differentiation

Dai, Xiuju, Sayama, Koji, Shirakata, Yuji, Hanakawa, Yasushi, Yamasaki, Kenshi, Tokumaru, Sho, Yang, Lujun, Wang, Xiaoling, Hirakawa, Satoshi, Tohyama, Mikiko, Yamauchi, Toshimasa, Takashi, Kadowaki,

Journal:

The Journal of Investigative Dermatology

Year:

2007

Language:

english

File:

PDF, 168 KB

english, 2007

12

Correlation between SPINK5 Gene Mutations and Clinical Manifestations in Netherton Syndrome Patients

Takehara, Kazuhiko, Komatsu, Nahoko, Saijoh, Kiyofumi, Jayakumar, Arumugam, Clayman, Gary L, Tohyama, Mikiko, Suga, Yasushi, Mizuno, Yuki, Tsukamoto, Katsuhiko, Taniuchi, Katsushige

Journal:

The Journal of Investigative Dermatology

Year:

2007

Language:

english

File:

PDF, 4.88 MB

english, 2007

13

Human herpesvirus 6 impairs differentiation of monocytes to dendritic cells

Hironari Niiya, Jin Lei, Yun Guo, Taichi Azuma, Yoshihiro Yakushijin, Ikuya Sakai, Takaaki Hato, Mikiko Tohyama, Koji Hashimoto, Masaki Yasukawa

Journal:

Experimental Hematology

Year:

2006

Language:

english

File:

PDF, 633 KB

english, 2006

14

IFN-α Enhances IL-22 Receptor Expression in Keratinocytes: A Possible Role in the Development of Psoriasis

Tohyama, Mikiko, Yang, Lujun, Hanakawa, Yasushi, Dai, Xiuju, Shirakata, Yuji, Sayama, Koji

Journal:

The Journal of Investigative Dermatology

Year:

2012

Language:

english

File:

PDF, 1.44 MB

english, 2012

15

SOCS3/CIS3 negative regulation of STAT3 in HGF-induced keratinocyte migration

Sho Tokumaru, Koji Sayama, Kenshi Yamasaki, Yuji Shirakata, Yasushi Hanakawa, Yoko Yahata, Xiuju Dai, Mikiko Tohyama, Lujun Yang, Akihiko Yoshimura, Koji Hashimoto

Journal:

Biochemical and Biophysical Research Communications

Year:

2005

Language:

english

File:

PDF, 448 KB

english, 2005

16

dsRNA-mediated innate immunity of epidermal keratinocytes

Mikiko Tohyama, Xiuju Dai, Koji Sayama, Kenshi Yamasaki, Yuji Shirakata, Yasushi Hanakawa, Sho Tokumaru, Yoko Yahata, Lujun Yang, Hiroshi Nagai, Akira Takashima, Koji Hashimoto

Journal:

Biochemical and Biophysical Research Communications

Year:

2005

Language:

english

File:

PDF, 2.95 MB

english, 2005

17

Nuclear translocation of phosphorylated STAT3 regulates VEGF-A-induced lymphatic endothelial cell migration and tube formation

Hideki Okazaki, Sho Tokumaru, Yasushi Hanakawa, Ken Shiraishi, Yuji Shirakata, Xiuju Dai, Lijun Yang, Mikiko Tohyama, Koji Hashimoto, Koji Sayama

Journal:

Biochemical and Biophysical Research Communications

Year:

2011

Language:

english

File:

PDF, 783 KB

english, 2011

18

The influence of hepatic damage on serum soluble Fas ligand levels of patients with drug rashes

Tohyama, Mikiko, Shirakata, Yuji, Sayama, Koji, Hashimoto, Koji

Journal:

Journal of Allergy and Clinical Immunology

Year:

2009

Language:

english

File:

PDF, 96 KB

english, 2009

19

Fluctuation of blood and skin plasmacytoid dendritic cells in drug-induced hypersensitivity syndrome

Sugita, Kazunari, Tohyama, Mikiko, Watanabe, Hideaki, Otsuka, Atsushi, Nakajima, Saeko, Iijima, Masafumi, Hashimoto, Koji, Tokura, Yoshiki, Miyachi, Yoshiki, Kabashima, Kenji

Journal:

Journal of Allergy and Clinical Immunology

Year:

2010

Language:

english

File:

PDF, 276 KB

english, 2010

20

Mite allergen is a danger signal for the skin via activation of inflammasome in keratinocytes

Dai, Xiuju, Sayama, Koji, Tohyama, Mikiko, Shirakata, Yuji, Hanakawa, Yasushi, Tokumaru, Sho, Yang, Lujun, Hirakawa, Satoshi, Hashimoto, Koji

Journal:

Journal of Allergy and Clinical Immunology

Year:

2011

Language:

english

File:

PDF, 1.12 MB

english, 2011

21

TGF-β is not involved in early phase growth inhibition of keratinocytes by 1α,25(OH)2vitamin D3

Shirakata, Yuji, Ueno, Hikaru, Hanakawa, Yasushi, Kameda, Kenji, Yamasaki, Kenshi, Tokumaru, Sho, Yahata, Yoko, Tohyama, Mikiko, Sayama, Koji, Hashimoto, Koji

Journal:

Journal of Dermatological Science

Year:

2004

Language:

english

File:

PDF, 302 KB

english, 2004

22

Bone morphogenetic protein-2 modulates Wnt and frizzled expression and enhances the canonical pathway of Wnt signaling in normal keratinocytes

Yang, Lujun, Yamasaki, Kenshi, Shirakata, Yuji, Dai, Xiuju, Tokumaru, Sho, Yahata, Yoko, Tohyama, Mikiko, Hanakawa, Yasushi, Sayama, Koji, Hashimoto, Koji

Journal:

Journal of Dermatological Science

Year:

2006

Language:

english

File:

PDF, 439 KB

english, 2006

23

Epiregulin, a member of the EGF family, is over-expressed in psoriatic epidermis

Shirakata, Yuji, Kishimoto, Jiro, Tokumaru, Sho, Yamasaki, Kenshi, Hanakawa, Yasushi, Tohyama, Mikiko, Sayama, Koji, Hashimoto, Koji

Journal:

Journal of Dermatological Science

Year:

2007

Language:

english

File:

PDF, 537 KB

english, 2007

24

PPARγ is an important transcription factor in 1α,25-dihydroxyvitamin D3-induced involucrin expression

Dai, Xiuju, Sayama, Koji, Shirakata, Yuji, Tokumaru, Sho, Yang, Lujun, Tohyama, Mikiko, Hirakawa, Satoshi, Hanakawa, Yasushi, Hashimoto, Koji

Journal:

Journal of Dermatological Science

Year:

2008

Language:

english

File:

PDF, 544 KB

english, 2008

25

Living skin equivalents constructed using human amnions as a matrix

Yang, Lujun, Shirakata, Yuji, Tokumaru, Sho, Xiuju, Dai, Tohyama, Mikiko, Hanakawa, Yasushi, Hirakawa, Satoshi, Sayama, Koji, Hashimoto, Koji

Journal:

Journal of Dermatological Science

Year:

2009

Language:

english

File:

PDF, 868 KB

english, 2009

26

PPARγ mediates innate immunity by regulating the 1α,25-dihydroxyvitamin D3 induced hBD-3 and cathelicidin in human keratinocytes

Dai, Xiuju, Sayama, Koji, Tohyama, Mikiko, Shirakata, Yuji, Hanakawa, Yasushi, Tokumaru, Sho, Yang, Lujun, Hirakawa, Satoshi, Hashimoto, Koji

Journal:

Journal of Dermatological Science

Year:

2010

Language:

english

File:

PDF, 564 KB

english, 2010

27

Interactions between myofibroblast differentiation and epidermogenesis in constructing human living skin equivalents

Yang, Lujun, Hashimoto, Koji, Tohyama, Mikiko, Okazaki, Hidenori, Dai, Xiuju, Hanakawa, Yasushi, Sayama, Koji, Shirakata, Yuji

Journal:

Journal of Dermatological Science

Year:

2012

Language:

english

File:

PDF, 1.67 MB

english, 2012

28

Differentiated keratinocytes are responsible for TNF-α regulated production of macrophage inflammatory protein 3α/CCL20, a potent chemokine for Langerhans cells

Tohyama, Mikiko, Shirakara, Yuji, Yamasaki, Kenshi, Sayama, Koji, Hashimoto, Koji

Journal:

Journal of Dermatological Science

Year:

2001

Language:

english

File:

PDF, 297 KB

english, 2001

29

Lack of evidence for TARC/CCL17 production by normal human keratinocytes in vitro

Tsuda, Teruko, Tohyama, Mikiko, Yamasaki, Kenshi, Shirakata, Yuji, Yahata, Yoko, Tokumaru, Sho, Sayama, Koji, Hashimoto, Koji

Journal:

Journal of Dermatological Science

Year:

2003

Language:

english

File:

PDF, 232 KB

english, 2003

30

The cathelicidin (hCAP-18/LL-37) expression in the granules of leukocytes in the pustules and perhipheral blood with palmoplantar pustulosis

Murakami, Masamoto, Okazaki, Hidenori, Hanakawa, Yasushi, Tohyama, Mikiko, Shirakata, Yuji, Sayama, Koji

Journal:

Journal of Dermatological Science

Year:

2013

Language:

english

File:

PDF, 52 KB

english, 2013

31

CISH suppresses CCL20 production from epidermal keratinocytes in Th2 dominant environment

Tohyama, Mikiko, Shirakata, Yuji, Hanakawa, Yasushi, Dai, Xiuju, Okazaki, Hidenori, Murakami, Masamoto, Hashimoto, Koji, Sayama, Koji

Journal:

Journal of Dermatological Science

Year:

2013

Language:

english

File:

PDF, 57 KB

english, 2013

32

TNF-α as a useful predictor of human herpesvirus-6 reactivation and indicator of the disease process in drug-induced hypersensitivity syndrome (DIHS)/drug reaction with eosinophilia and systemic symptoms (DRESS)

Uno, Hirokazu, Kabashima, Kenji, Tohyama, Mikiko, Watanabe, Tsunamasa, Hashimoto, Koji, Iijima, Masafumi, Sueki, Hirohiko, Watanabe, Hideaki

Journal:

Journal of Dermatological Science

Year:

2014

Language:

english

File:

PDF, 296 KB

english, 2014

33

Infantile inflammatory pseudotumor of the facial nerve as a complication of epidermal nevus syndrome with cholesteatoma

Hato, Naohito, Tsujimura, Mika, Takagi, Taro, Okada, Masahiro, Gyo, Kiyofumi, Tohyama, Mikiko, Tauchi, Hisamichi

Journal:

Auris Nasus Larynx

Year:

2013

Language:

english

File:

PDF, 1.07 MB

english, 2013

34

Ragweed pollen activates inflammasome in epidermal keratinocytes and release IL-1beta and IL-18

Dai, Xiuju, Tohyama, Mikiko, Shirakata, Yuji, Hanakawa, Yasushi, Okazaki, Hidenori, Murakami, Masamoto, Sayama, Koji

Journal:

Journal of Dermatological Science

Year:

2013

Language:

english

File:

PDF, 59 KB

english, 2013

35

Bromoderma caused by over-the-counter analgesic mimicking pyoderma gangrenosum

Fumiko Oda,Mikiko Tohyama,Koji Sayama

Journal:

Clinical and Translational Allergy

Year:

2014

Language:

english

File:

PDF, 266 KB

english, 2014

36

Infantile generalized pustular psoriasis: Successful disease control with intermittent etretinate

Namba, Chika, Murakami, Masamoto, Hanakawa, Yasushi, Tohyama, Mikiko, Shirakata, Yuji, Tauchi, Hisamichi, Sayama, Koji

Journal:

The Journal of Dermatology

Year:

2014

Language:

english

File:

PDF, 348 KB

english, 2014

37

Pressure sore-like ulcers on acneiform papules caused by EGFR inhibitors

Miyawaki, Saori, Tohyama, Mikiko, Irifune, Kazunori, Ito, Ryouji, Sayama, Koji

Journal:

International Wound Journal

Year:

2014

Language:

english

File:

PDF, 675 KB

english, 2014

38

Immunological mechanisms of epidermal damage in toxic epidermal necrolysis

Tohyama, Mikiko, Hashimoto, Koji

Journal:

Current Opinion in Allergy and Clinical Immunology

Year:

2012

Language:

english

File:

PDF, 258 KB

english, 2012

39

Severe Hypersensitivity Syndrome Due to Sulfasalazine Associated With Reactivation of Human Herpesvirus 6

Tohyama, Mikiko, Yahata, Yoko, Yasukawa, Masaki, Inagi, Reiko, Urano, Yoshio, Yamanishi, Koichi, Hashimoto, Koji

Journal:

Archives of Dermatology

Year:

1998

Language:

english

File:

PDF, 285 KB

english, 1998

40

High Frequency of HLA B62 in Fulminant Type 1 Diabetes with the Drug-Induced Hypersensitivity Syndrome

Onuma, Hiroshi, Tohyama, Mikiko, Imagawa, Akihisa, Hanafusa, Toshiaki, Kobayashi, Tetsuro, Kano, Yoko, Ohashi, Jun, Hashimoto, Koji, Osawa, Haruhiko, Makino, Hideichi

Journal:

Journal of Clinical Endocrinology & Metabolism

Year:

2012

File:

PDF, 387 KB

2012

41

High Frequency of HLA B62 in Fulminant Type 1 Diabetes with the Drug-Induced Hypersensitivity Syndrome

Onuma, Hiroshi, Tohyama, Mikiko, Imagawa, Akihisa, Hanafusa, Toshiaki, Kobayashi, Tetsuro, Kano, Yoko, Ohashi, Jun, Hashimoto, Koji, Osawa, Haruhiko, Makino, Hideichi

Journal:

Journal of Clinical Endocrinology & Metabolism

Year:

2012

Language:

english

File:

PDF, 387 KB

english, 2012

42

Occupational Trichloroethylene Hypersensitivity Syndrome with Human Herpesvirus-6 and Cytomegalovirus Reactivation

Watanabe, Hideaki, Tohyama, Mikiko, Kamijima, Michihiro, Nakajima, Tamie, Yoshida, Takemi, Hashimoto, Koji, Iijima, Masafumi

Journal:

Year:

2010

Language:

english

File:

PDF, 436 KB

english, 2010

43

Human herpesvirus 6 and drug allergy

Hashimoto, Koji, Yasukawa, Masataka, Tohyama, Mikiko

Journal:

Current Opinion in Allergy and Clinical Immunology

Year:

2003

Language:

english

File:

PDF, 112 KB

english, 2003

44

Case of palmoplantar pustulosis that developed with acute glomerulonephritis

Masuda, Kana, Murakami, Masamoto, Ohnishi, Sachiko, Kukida, Masayoshi, Hanakawa, Yasushi, Tohyama, Mikiko, Sayama, Koji

Journal:

The Journal of Dermatology

Year:

2015

Language:

english

File:

PDF, 448 KB

english, 2015

45

A Case of Histopathologically Typical Toxic Epidermal Necrolysis Despite No Visible Blisters or Erosive Lesions

Kakeda, Masato, Tohyama, Mikiko, Iwasaki, Junji, Hashimoto, Koji, Mizutani, Hitoshi

Journal:

The Journal of Dermatology

Year:

2005

Language:

english

File:

PDF, 139 KB

english, 2005

46

Bromoderma mimicking pyoderma gangrenosum caused by commercial sedatives

Oda, Fumiko, Tohyama, Mikiko, Murakami, Akiko, Kanno, Kazuhisa, Sonobe, Naomi, Sayama, Koji

Journal:

The Journal of Dermatology

Year:

2016

Language:

english

File:

PDF, 458 KB

english, 2016

47

Sequelae in 145 patients with drug-induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms: Survey conducted by the Asian Research Committee on Severe Cutaneous Adverse Reactions (ASCAR)

Kano, Yoko, Tohyama, Mikiko, Aihara, Michiko, Matsukura, Setsuko, Watanabe, Hideaki, Sueki, Hirohiko, Iijima, Masafumi, Morita, Eishin, Niihara, Hiroyuki, Asada, Hideo, Kabashima, Kenji, Azukizawa, Hi

Journal:

The Journal of Dermatology

Year:

2015

Language:

english

File:

PDF, 233 KB

english, 2015

48

Paraneoplastic pemphigus associated with fatal bronchiolitis obliterans and intractable mucosal erosions: Treatment with cyclosporin in addition to steroid, rituximab and intravenous immunoglobulin

Namba, Chika, Tohyama, Mikiko, Hanakawa, Yasushi, Murakami, Masamoto, Shirakata, Yuji, Matsumoto, Takuya, Suemori, Koichiro, Ishii, Norito, Hashimoto, Takashi, Sayama, Koji

Journal:

The Journal of Dermatology

Year:

2016

Language:

english

File:

PDF, 564 KB

english, 2016

49

Drug-Induced Hypersensitivity Syndrome due to Mexiletine Associated with Human Herpes Virus 6 and Cytomegalovirus Reactivation

Sekiguchi, Atsushi, Kashiwagi, Takayuki, Ishida-Yamamoto, Akemi, Takahashi, Hidetoshi, Hashimoto, Yoshio, Kimura, Hiroshi, Tohyama, Mikiko, Hashimoto, Koji, Iizuka, Hajime

Journal:

The Journal of Dermatology

Year:

2005

Language:

english

File:

PDF, 49 KB

english, 2005

50

Two cases of genital neutrophilic sebaceous adenitis

Tohyama, Mikiko, Matsumoto, Keiko, Sayama, Koji

Journal:

The Journal of Dermatology

Year:

2016

Language:

english

File:

PDF, 529 KB

english, 2016

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